Zofran
DESCRIPTION

Zofran is the trade name of a generic drug called Ondansetron. This drug is designed to avert nausea and vomiting. It comes in the form of tablets as well as an oral solution.

How It Works

The precise mechanism by which Zofran prevents nausea is yet to be identified. This medication is metabolized when absorbed into the body through the gastrointestinal tract. This process is responsible for blocking nausea. Another possible explanation is that this drug directly impacts the part of the brain known as CTZ which is connected with vomiting. The chemoreceptor trigger zone (CTZ) functions by receiving inputs from drugs in the blood and interacts with other areas such as area postrema to instigate vomiting. Zofran is able to successfully inhibit this process.

It is also known that serotonin; a neurotransmitter primarily located in the gastrointestinal tract plays a key role in breaking down Zofran and helping your body absorb the drug better.

Uses

The chief use of this drug is to prevent nausea that results from chemotherapy, radiation treatment or surgery. It is also prescribed to cure Gastroenteritis, a type of infectious diarrhea. However, this drug is not effective in preventing nausea instigated by kinetosis or motion sickness.

Dosage

Zofran is usually given to patients before a surgery is done. This drug should be taken 30 minutes before chemotherapy begins. In the case of radiation therapy, Zofran should be taken at least 2 hours prior to treatment. To prevent nausea that results after surgery, this drug should be taken 1 hour before the surgery.

If you prefer to take the oral solution, use a measuring spoon or cup to get the prescribed quantity correctly. Zofran is usually prescribed to be taken 3 times a day which is to be continued for 2 or more days until treatment is ended.

Side Effects

Some of the common side effects of Zofran are listed below. If you find any of it too bothersome, seek medical care straightway.

Constipation
Anxiety
Dry mouth
Trembling
Hyperventilation
Insomnia
Dizziness
Fever
Shortness of breath
Headache
Weakness

With the intake of this drug, it is possible that the level of serotonin in your body upsurges and causes a condition known as serotonin toxicity. It is a very rare side effect.

It is seldom that a person develops a severe allergic reaction to Zofran. Symptoms of an allergy include skin rashes and swelling of the tongue or throat area.

Precautions

Be aware of any other drugs which can increase the level of serotonin in your body while taking Zofran. To avoid this, produce a prescription of other drugs you are taking at the time being to your doctor or pharmacist.

Let your doctor be informed of any of the following conditions you have experienced before taking Zofran.

Problems in the digestive tract
Liver disease
Heart problems
QT prolongation

Children below 4 years of age should not be given Zofran.

Self-Care

Zofran can cause dizziness once taken. Be careful if you are occupied with any work that requires your attentiveness. To diminish the feeling of dizziness, avoid making sudden and harsh movements.

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